TURNOVER OF LABELED NORMAL GAMMA GLOBULIN IN MULTIPLE MYELOMA*
نویسندگان
چکیده
منابع مشابه
Turnover of Labeled Normal Gamma
Aberrations of protein metabolism in multiple myeloma have been studied by a number of investigators (1-6) to ascertain whether the globulins in the blood consist of excesses of normal globulins or of chemically abnormal globulins, or both. Such research has been directed toward determining whether "characteristic protein abnormalities" could be distinguished by 1) separation of the serum prote...
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Increased catabolism of plasma proteins by leakage into the gastrointestinal tract and subsequent digestion by the intestinal enzymes are frequently the causes of hypoproteinemia (1-5). The presence of plasma proteins has been demonstrated both in saliva and in the gastric and intestinal juice of normal individuals; therefore, gastrointestinal leakage of plasma proteins may account for a substa...
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The turnover of (131)I-labeled gamma globulin has been determined in rabbits before and during (8 weeks later) hyperimmunization with pneumococcic vaccine, which increased the gamma globulin concentration 5 to 10 times. Before immunization fractional turnover rate was an average of 36 per cent of the plasma pool per day, and the rate of catabolism was 133 mg/kg/day. During hyperimmunization fra...
متن کاملSedimentation analysis of a multiple myeloma gamma-G-globulin and one of its mercaptoethylamine reaction products.
Descriptions of some thermodynamic properties and transport behavior in solution of an intact multiple myeloma yG-globulin and of one of the products of its reaction with mercaptoethylamine have been provided. For the sedimentation equilibrium experiments, the parent yG-globulin was dissolved in three solvent systems: cacodylate buffer, its 8 M urea solution and its 6 M guanidine hydrochloride ...
متن کاملTreatment of Multiple Myeloma
Les traitements classiques de myelome multiple et les schemas differents proposes ont ete mis en revue. La poly chimiotherapie de la maladie avec une com-binaison de cyclophosphamide, B.C.N.U. Alkeran, Perdnisone et Vincristine a donnee une meilleur Resultat ceci surtout dans les formes graves et rapidement progressive de la maladie. D'autres sehemas therapeutiques sont en cours.
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1960
ISSN: 0021-9738
DOI: 10.1172/jci104069